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Early in the Grey's run, George earned the nickname "007" because he had a "license to kill." It's this very nickname that allows Meredith to identify him as the John Doe who saves the old lady from getting hit by a bus. George is injured so badly he is completely unrecognizable when he arrives in the ER, and he has to sign the numbers "007" into Meredith's hand so she would know this is him. Although this isn't technically foreshadowing and falls more under the "irony" tab, it's still a boss move on the part of the writing staff.