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Way back in season two, before there was a Post-It wedding (or a real wedding, for that matter), or any children, or before half of the calamities that eventually befall Meredith and Derek, they were merely star-crossed lovers and heart-eyed emoji. They were so in love, Derek regularly said things like this to Meredith: "It's like I was drowning, and you saved me." This is very sweet, but also wildly cryptic; merely one season later, Derek is the one who saves Meredith from drowning during the ferry crash.