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George's decision to marry Callie right after his father's death may not be the best decision he's ever made, but he sticks to it. Unsurprisingly, George and Callie's marriage is rocky from the start. There's not much chemistry between them, which isn't helped by George's obsession with Izzie. George and Izzie have been best friends since day one, however, it's only when George becomes unavailable that Izzie's true feelings come out. A classic tale of "you don't know what you've got till it's married."