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If you want to see a masterclass in villainy, Mikkelsen's role as Le Chiffre in 2006's "Casino Royale" is one of the best. James Bond (Daniel Craig) finds himself entangled with the French financier of terrorism in a dangerous game of cat and mouse (and Texas Hold 'Em). At one point, Le Chiffre comes dangerously close to cutting off Bond's manhood, and honestly we've never been able to look at Mikkelsen the same way since.