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After stints writing episodes of Mad About You, Gilmore Girls, and Will & Grace, Jenji Kohan created a series that remains one of Showtime's biggest hits to this day: Weeds. The comedy gave Mary-Louise Parker a chance to shine as Nancy Botwin, a single mother who begins selling marijuana in order to provide for her children. Nancy was a pioneer for women in primetime, a sexually unapologetic antihero who refuses to kowtow to the parade of dangerous men in her life. The role earned Parker a Golden Globe, and the show ran for eight seasons.