Season 2, episode 17: "As We Know It"
"As We Know It" will forever go down in the Grey’s Anatomy fandom as the bomb episode, not in that it was awesome (which it was) but in that there was literally a bomb inside someone. In this episode, sweet, self-sacrificing, dark, and twisted Meredith sticks her hand into a patient's open chest cavity that contains a homemade explosive. Mer survives, but not without first racking our nerves to the tune of Anna Nalick's affected "Breathe." Sadly, bomb squad guy (played by guest star Kyle Chandler) doesn't survive, but he appears in a later episode. At the end of the episode, Derek reminds Meredith about the time when they last kiss. Ugh. This episode rightfully earned writer Shonda Rhimes an Emmy nomination.