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50/50 isn't afraid to show the nitty-gritty realities of what a person with cancer struggles with on a day-to-day basis, from shaved heads ("No one wants to f*ck me, I look like Voldemort") to not being able to move without vomiting. The bond between best friends Adam (Joseph Gordon-Levitt) and Kyle (Seth Rogen) gives the movie its heart, and there's also a little romance thrown in thanks to Anna Kendrick's endearing therapist character, Katherine.