We don't know too much about the specifics of Venom, other than it will be an origin story. Venom originally popped up in Marvel comics in 1988 and has remained one of Spider-Man's most popular enemies ever since. As Sam Raimi's Spider-Man 3 shows, Venom is a gooey, black alien Symbiote that can only survive if it attaches itself to a human. Once it does, the human gains incredible powers and a flair for evil.
Since we know that Venom won't feature a showdown with Spider-Man and will instead keep Venom as the main focus, there's a good chance he won't face off against any other marquee names like Iron Man or the Hulk. It will likely revolve around Eddie Brock's initial infection and how he handles his new abilities (not great, we assume).
