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Also known as the candle house episode, this might be the best MerDer episode of all time, and it undoubtedly includes the show's greatest romantic gesture. Leading up to this episode, Meredith and Derek have broken up again, and Derek briefly dates Rose, a nurse. The former couple remain professional as they run a clinical trial together. However, after their last patient pulls through, showing their trial is working, Derek runs to Meredith's house looking for her, but she's actually at the land he's bought. She creates a blueprint of their home together out of candles and — slightly angry that he was late showing up — tells him her plans for them and their life together. "I believe that we can be extraordinary together, rather than ordinary apart," she says, and he finally kisses her — but stops when he remembers he still has to break up with Rose. Rose never stood a chance.