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Following Rebecca's diagnosis of mild cognitive impairment, her condition begins progressing to Alzheimer's throughout season six. While struggling to hold on to the cherished memories she created with her family, Rebecca's health rapidly deteriorates as she comes to terms with her affliction and what it will mean for her family after she's gone. Foreseeing the challenges ahead, she appoints Kate as her primary caretaker on the off chance her husband, Miguel, isn't able to provide the help she requires.
Though the family spends as much of their time with Rebecca as possible, things take a turn for the worse when Miguel passes away. Rebecca becomes less and less functional until the time comes when the family is informed that they should rush to say their goodbyes to the Pearson matriarch. The whole clan gathers to pay their respects to Rebecca, who is barely conscious of her surroundings, but we see her heartwarming journey into the Afterlife as she, at long last, is reunited with her late husband, Jake. Though Rebecca's still terrified of leaving behind her kids, Jack reassures her that the kids will always have a part of her within them no matter the distance. Realizing this, Rebecca finally lets go of her worries and dies peacefully in the penultimate episode, with the finale episode centered on her funeral.