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The highly addictive painkiller that helps Fortunato build a billion-dollar empire is called Ligodone on the show. The name is supposedly derived from Poe's 1838 short story "Ligeia." However, Ligodone could very well have been inspired by the real-life opium laudanum, which Poe tried to overdose on in the year prior to his death. The show also reveals the name of the scientist who came up with Ligodone to be Metzer, which is short for "Metzengerstein," a likely allusion to Poe's first published story that came out in 1832.