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What to do: You'll want to bring walking shoes! Guayaquil is steeped in history, and it's best seen by exploring. Start by walking through the small towns, walking into churches and prayer rooms, like Capilla Hospicio del Corazón de Jesús, and finish off a day of adventure by exploring the Malecón 2000.
Where to eat: Marrecife Marisquería is where the locals eat, which means the food is probably otherworldly. This marisquería is all that is good about Ecuador's seafood-based cooking.
Where to stay: The Wyndham Hotel has the best of both worlds — all of the modern perks of a comfortable hotel stay and all that Guayaquil has to offer right outside its door.