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"The key ingredient in Pepto-Bismol is bismuth, a metal 86% the density of lead, hence the weight of a bottle of the stuff. Bismuth is used because it is toxic to some bacteria that cause diarrhea (along with some other nifty characteristics), but a genius science teacher I had in junior high told me the weight of the bismuth allows it to displace stomach contents very effectively and reach the source of your problems." — Reddit user JimmyLongnWider