9 Reasons Louisville, KY, Should Be on Your Travel Radar

Not only does this hotel offer you a place to rest your weary (or bourbon-filled!) head, but it also houses a museum designed to showcase contemporary art. Five 19th century warehouses live on as more than 9,000 square feet of exhibition space where curated exhibitions and site-specific installations reflect the global nature of contemporary culture. The bar and restaurant, Proof on Main, carry more than 120 types of Kentucky bourbons and are full of lively pops of color.

21C also offers a once-in-a-lifetime sleeping experience. "Asleep in the Cyclone" is a completely immersive art experience that includes a king bed and unique amenities.