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33 Songs From Grey's Anatomy Guaranteed to Make You Sob Uncontrollably
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“Real Life” by Imagine Dragons

  • When it destroyed you: Season 16, episode 15
  • Why it destroyed you: Jo breaks down in tears and confides in Link after she realizes that Alex left her. It's later revealed that Alex returned to his life in Seattle to reunite with his first wife, Izzie Stevens. Oh, and it turns out that Alex is also the father of Izzie's 5-year-old twins. Needless to say, Grey's fans were none too pleased with Alex's exit.
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