Grey's Anatomy Alumni: Where Are They Now?

Before med school, Izzie was a model, but she comes determined to be taken seriously as a doctor. Along the way, she has many love interests, including George O'Malley and Alex Karev. She has a health scare with a brain tumor. Heigl's exit from the show came from off-camera drama between her and Shonda Rhimes. Her character ended up divorcing Karev and leaving Seattle in season six.