The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

After Derek's death, Meredith's first genuine love interest is Nathan, a cardio surgeon who has a complicated past with Owen Hunt. It's slowly revealed that Nathan was engaged to Owen's sister Megan when she went missing, and Owen blames Nathan for Megan's disappearance. Over time, Nathan and Meredith grow close and start a relationship, but it ends messily when Megan reappears very much alive. Although it's sad for Meredith to lose him, his departure is pretty low-key by Grey's standards.