The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

Alzheimer's has been a constant presence on Grey's, from Ellis Grey and Meredith's fears of developing it herself, to the research of the neurosurgeons. It's particularly heartbreaking to watch Adele Webber's decline as she slowly loses her memories and her sense of self. In the end, her husband Richard is left to grieve her on the very same night that he's trying to be a supportive friend at Bailey and Ben's wedding.