The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

Oh, Little Grey, we still cry when we think about this death! Meredith's little sister starts out as the hyper, perky counterpart to her "dark and twisty" half-sister, but she slowly becomes a fascinating and complicated character. Her on-and-off romance with Mark also becomes one of the show's great, epic loves. Sadly, they never get their happily-ever-after, as Lexie gets pinned beneath the wreckage during the season eight plane crash finale. Mark holds her hand and narrates the life they should have had in her final moments, in a scene that is impossible not to cry through while watching.