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And we all laughed through tears, because we knew their time was so limited.
Alex and Izzie's love story was a long time coming, and we shipped them hard, even before shipping was even a thing. They got married at what was supposed to be Meredith and Derek's wedding, and the subsequent love story that plays out amid Izzie's cancer is an insane test to what a viewer is willing to put up with in any given season of a TV season.