After Kit Walker and his wife are attacked in their home in the 1960s (something he initially thinks is because they are an interracial couple), she goes missing and he is sent to a corrupt insane asylum, Briarcliff Mental Institution, for her murder. He then reveals that he thinks it was actually aliens who abducted his wife, but the asylum's staff, headed by Sister Jude, doesn't believe him. He befriends a journalist named Lana Winters, who travels to Briarcliff with the hope of interviewing a serial killer called "Bloody Face." She then ends up being admitted to Briarcliff after she threatens to expose their darkest secrets, which include horrific experiments on patients.
Lana eventually bonds with psychiatrist Dr. Oliver Thredson, who sees her sanity and wants to help her escape. But when he successfully gets her out of Briarcliff, a whole new hell starts when she realizes that he is actually "Bloody Face." Meanwhile, Kit has relations with a fellow inmate who also ends up getting abducted by aliens. When she returns, she has his baby and he eventually organizes their release. When they return to his home, they find Alma alive and with a baby of her own.
