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Of all the catastrophes in Grey's Anatomy's 12 seasons, McDreamy's death may have been the most traumatic — and it seems like Shonda Rhimes and company knew all along he was going to die. In the second episode of the first season, Derek tells Meredith, "You know I have four sisters? Very girlie, tons of kids. If I was in a coma, they'd all be here. I'd want them here."