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ABC's 1989 sitcom Family Matters follows the daily life of the Winslow family, including police officer Carl (Reginald VelJohnson), his wife Harriet (Jo Marie Payton), and their three children. The family is frequently visited by their pesky neighbor, Urkel (Jaleel White). Intelligent but extremely socially awkward, Urkel causes many of the laughs throughout the show's nine-season run.
There are also numerous crossover episodes that air throughout the series, including ones with Full House, Boy Meets World, Step by Step, and Perfect Strangers, the latter of which Family Matters was a spinoff of.
Fun Fact: Jo Marie Payton voices Suga Mama in Disney Channel's The Proud Family.