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Sara Gilbert gave us major sass in the role of middle child Darlene Conner. Taking after her mother's signature snark and gift of gab, the second oldest of the Conner kids was always delivering hilarious one-liners, be it in a war of words with her parents, teasing her younger brother, or poking fun at her boyfriend (and later husband), David Healy, Mark's brother.
Darlene, now divorced from David, is left back in the Conner house with daughter Harris and gender-fluid son Mark, named after their uncle.