10 Grey's Anatomy Breakups That Destroyed Our Fragile Hearts

We shipped Calzona so freakin' hard that it stung when their relationship crumbled into pieces. The makings of their breakup start with Callie's call to amputate Arizona's leg after the plane crash, and soon after, Arizona begins to feel misunderstood by her wife, which results in a brief affair. When their therapist asks them to spend time apart, Callie realizes she's happier alone. Goodbye, existence of true love.

Watch it here.