17 Longest Running TV Shows of All Time, From "Grey's Anatomy" to "SVU"

• Seasons: 19
• Episodes: 420+ (Ongoing)

In terms of popular TV show genres, nothing can compete with medical dramas. "Grey's Anatomy" follows a group of interns and residents at Seattle Grace Hospital (now, Grey Sloan Memorial) as they study to become doctors, all while balancing steamy flings, workplace relationships, and personal issues. The show's 19th season premiered in October 2022, and marked Meredith Grey's (played by Ellen Pompeo) final season as a series regular.