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Giuliana Rancic went through a four-year infertility struggle before she became the proud mother of Edward Duke via surrogacy. Nothing could have prepared her for being told that she was unable to have kids naturally, she told Health magazine in a 2012 interview, per CNN:
"I always say how I chased my career instead of chasing guys. And everybody was patting me on the back. No one ever told me, 'Oh, by the way, your eggs change when you reach a certain age.' I didn't think 35 was old! So when the doctor said, 'It's not as easy as you thought it would be,' it was a real blow. Because I felt so young. I mean, this is a girl who was running six miles a day, and eating healthy, so how can you tell me that I'm not healthy in that department?"