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Does CBD Have Negative Side Effects?

CBD's Side Effects Are Rare and Mild, but There's 1 Major Consideration

The World Health Organization reported that CBD is safe and has no health risks, but there may still be rare and mild side effects. Research is just beginning to unfold, but here's what we know so far.

POPSUGAR spoke with several medical doctors to find out if there were common negative side effects, and the only one of significance was CBD's ability to interact with other medications. "THC is processed in the liver by an enzyme that doesn't do a lot, whereas the enzyme that handles CBD handles pretty much all conventional medications," said Dr. Jordan Tishler, MD. "It's a busy enzyme; if you overwhelm it with CBD, you get level changes with other medications."

This means that CBD potentially poses NO side effects if you're not taking other medications, but if you are taking medications, it could change the level of how much your body absorbs of said medication. In this instance, it's imperative that you work with a doctor before beginning any kind of CBD regimen.


Not a ton of research has been done yet, so there aren't conclusive claims as to whether or not there are additional side effects. Medium reported that because of the stigma around cannabis, scientific researchers "struggled through years of red tape and put their careers at risk in order to promote the need for this vital research."

One study in 1986 in the International Journal of Neuroscience looked at five patients with movement disorders like Parkinson's (read: very, very small study) and found that there were some very mild side effects, including: "hypotension, dry mouth, psychomotor slowing, lightheadedness, and sedation." The study also noted that two out of the five patients experienced slightly worse tremors, while the other three saw more positive effects. Again, this study was very small and took place over 30 years ago, but it's something to keep in mind.

Because CBD is nonpsychoactive, you won't feel high or intoxicated. Everyone's body is different, so keep a journal of when you take it, how much you're taking, what delivery was used, and how you felt. And we know you know, but a reminder: before beginning any kind of new medicinal treatment, it's best to speak with your doctor first.

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