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"Taking the pill with some medications can render it less effective," Dr. Landa said. For example, the antibiotic rifampin — which is usually prescribed for tuberculosis but may be used to treat other infections — can interfere with the pill. "Others include anti-seizure medications like tripleptal, tegretol, and dilatin, [as well as] some antifungal drugs like griseofulvin and ketoconazole," she said. There are more, so list all your medications for your physician when discussing your options, and when in doubt, use a condom.