While Amelia Shepherd (Caterina Scorsone) is open about the fact that she's a recovering drug addict, she's managed to stay mostly sober, with only one brief relapse, since joining the cast of Grey's Anatomy. Since she's managed to hold onto her sobriety through the loss of her brother, the dissolution of her marriage, a brain tumor, and most recently, the loss of her foster daughter, it may be tempting to assume that nothing could shake her off the wagon at this point.
However, anyone who watched Amelia's arc on the Grey's spinoff Private Practice knows just how easy it is for Amelia to slip back into her old, destructive habits and how difficult it is for her to resist the temptation to resort to pills and booze to numb the pain when life gets hard. Between the loss of Betty (Peyton Kennedy), the knowledge that Owen (Kevin McKidd) chose Teddy (Kim Raver) over Amelia, and the responsibility of possibly having to care for Meredith's three kids while her sister-in-law goes to jail, Amelia will be dealing with a lot of anxiety and pressure in season 16. And while of course we want to hope that the youngest Shepherd sister will continue to stand firm, planting her feet holding her superhero pose no matter what life throws at her, we wouldn't be surprised if season 16 had a wave big enough to finally knock her down.