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33 Songs From Grey's Anatomy Guaranteed to Make You Sob Uncontrollably
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"How to Save a Life" by The Fray

  • When it destroyed you: Season two, episode 21
  • Why it destroyed you: "It's a beautiful afternoon to save lives, people," Derek says just before a montage of the doctors trying to handle a number of crises at once. Years later, Owen sings it in the musical episode event "Song Beneath the Song" in season seven.
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