The Most Heartbreaking Character Exits on Grey's Anatomy, Ranked

Always a polarizing character, Izzie was one of the original "MAGIC" five interns, and she went through some major ups and downs during her time on the show. After barely surviving cancer and losing her best friend, Izzie struggles to try to return to normal. Ultimately, her exit is more shocking and frustrating than sad, as she leaves Seattle and breaks up with her husband Alex via letter.