"There's no good time to say goodbye to a show and character that's defined so much of my life for the past 15 years," Chambers said. "For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time."
Chambers is one of the few actors from the show's pilot who are still on the show, which is now in its 16th season and has been renewed through its 17th. He went on to thank Grey's creator Shonda Rhimes and the other remaining original cast members whom he has worked alongside over the past 15 years.
"As I move on from Grey's Anatomy, I want to thank the ABC family, Shonda Rimes, original cast members Ellen Pompeo, Chandra Wilson and James Pickens, and the rest of the amazing cast and crew, both past and present, and, of course, the fans for an extraordinary ride," he said.
According to TVLine, Chambers's last episode as Alex has already aired. His final appearance aired on Nov. 14, with the following episode on Nov. 21 revealing that Alex has returned home to care for his ailing mother. While there probably won't be any big sendoff, fans will definitely miss seeing the character on their screens — especially so soon after he finally tied the knot with Jo and the two might have been looking into expanding their family. We'll have to wait for the Winter return of Grey's to see how everyone handles Alex's abrupt exit!