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There was a time when margarine was considered the healthy alternative to butter. However, the truth is that some margarine contains a lot of trans fats, which is considered more unhealthy than any other fat, including saturated fats.
Trans fats increase bad cholesterol, which can lead to heart disease and stroke. Although the link between trans fatty acids and cancer is unclear, Johns Hopkins Medicine is just one institution that suggests lowering these fats as a part of their dietary recommendations for cancer patients and survivors.