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Having a drink to relax may do more harm than good. "Although it may seem as though it calms your nerves, alcohol can have a negative effect on hydration and sleep, both of which may trigger symptoms of anxiety," Vikram Tarugu, MD, gastroenterologist and CEO of Detox of South Florida, told POPSUGAR. He explained that anxiety results from alcohol changing serotonin levels and neurotransmitters in the brain, and you may feel even more anxious when the alcohol is wearing off.